Triethylamine → HCID 67373460, compound

HRID 1677001Notes

Reaction equation

HRID 1677001 reaction equation
Cl[S:2]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[N:7]([S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])[C:6]=1[C:24]([O:26][CH2:27][CH3:28])=[O:25])(=[O:4])=[O:3].C([N:31]([CH2:34]C)[CH2:32][CH3:33])C.C[CH2:37][O:38][C:39]([CH3:41])=O>ClCCl>[F:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C:6]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:5]2[S:2]([N:31]([CH2:32][CH2:33][NH:7][S:15]([C:18]1[CH:23]=[CH:41][C:39]([O:38][CH3:37])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[CH3:34])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 86605458HCID 86605458, compound

Product 1

HCID 67373460HCID 67373460, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Step A above (1 equivalent) was combined with the product from Step C above (1 equivalent) and triethylamine (3 equivalents) in dichloromethane and stirred at room temperature for 1.5 hours. The reaction was diluted with EtOAc, washed with saturated NaHCO3 and brine and dried over Na2SO4. Concentrating in vacuo gave the titled compound. ESI+ MS: 640 [MH—CH3]+.

Workup

  1. washwashed with saturated NaHCO3 and brine
  2. dry with materialdried over Na2SO4
  3. concentrationConcentrating in vacuo

Sources & evidence

ORD record
ord-9a1ef5dd0b114d778688460dda3c2aaa
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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