Hydrochloric Acid → HCID 67215725, compound

HRID 1677568Notes

Reaction equation

HRID 1677568 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[CH:11][C:12]2[N:13]([C:15]([C:18]([C:20]3[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[C:22]([O:29][CH3:30])[CH:21]=3)=[O:19])=[N:16][CH:17]=2)[CH:14]=1)=O)(C)(C)C.FC(F)(F)C(O)=O.Cl>>[NH2:8][C:9]1[CH:10]=[CH:11][C:12]2[N:13]([C:15]([C:18]([C:20]3[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[C:22]([O:29][CH3:30])[CH:21]=3)=[O:19])=[N:16][CH:17]=2)[CH:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 67215491HCID 67215491, compound

Product 1

HCID 67215725HCID 67215725, compound

Procedure

This compound is obtained according to the same process as that described in the preceding example 15 by deprotection of the amine of the compound [6-(tert-butoxycarbonylamino)imidazo[1,5-a]pyridin-3-yl](3-methoxy-4-nitrophenyl)methanone with trifluoroacetic acid. A yellow solid is obtained which is salified in the hydrochloride form. Melting point: 252° C.; 1H NMR (d6-DMSO): 4.01 (3H, s), 7.14 (1H, d), 7.79 (1H, s), 7.87 (1H, d), 7.97-8.01 (2H, m), 8.13 (1H, s), 9.41 (1H, s)

Workup

  1. customThis compound is obtained
  2. customA yellow solid is obtained which

Sources & evidence

ORD record
ord-5446f919b9e84be4977f2eec13601e07
Source dataset
uspto-grants-2011_08
Patent number
US08008321B2

Reaction notes

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