4-Methylmorpholine → HCID 16222130, compound

HRID 1678507Notes

Reaction equation

HRID 1678507 reaction equation
[CH:1]1([C:7]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([CH3:25])=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22](O)=[O:23])=[CH:18][CH:17]=3)[CH:15]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:26]=[S:27]1(=[O:42])[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([NH2:41])=[CH:37][CH:36]=2)[CH2:29][CH2:28]1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1>CN(C=O)C.O>[O:42]=[S:27]1(=[O:26])[CH2:28][CH2:29][N:30]([CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([NH:41][C:22]([C:19]3[CH:20]=[CH:21][C:16]([C:14]4[CH:15]=[C:10]([NH:9][C:7]([CH:1]5[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]5)=[O:8])[CH:11]=[CH:12][C:13]=4[CH3:25])=[CH:17][CH:18]=3)=[O:23])=[CH:37][CH:36]=2)[CH2:31][CH2:32]1

Participants

8

Reactant 5

HCID 79724-MethylmorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 43581170HCID 43581170, compoundHCID 59822383HCID 59822383, compound

Product 1

HCID 16222130HCID 16222130, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 5′-(Cyclohexanecarbonyl-amino)-2′-methyl-biphenyl-4-carboxylic acid (40 mg), 4-[2-(1,1-dioxo-1lambda*6*-thiomorpholin-4-yl)-ethyl]-phenylamine (30 mg), EDAC (23 mg), HOBT (16 mg) and N-Methylmorpholine (26 μl) in dry DMF (1 ml) was stirred for 16 hrs. This mixture was then diluted with water (8 ml) and the tan solid produced collected and dried (45 mg).

Workup

  1. customthe tan solid produced
  2. customcollected
  3. customdried (45 mg)

Sources & evidence

ORD record
ord-bbef08403bd9416293253e1c0f15d056
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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