Tetrahydrofuran → 1-(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclobutyl-1-(4-methylsulfanyl-phenyl)-ethanol

HRID 167853Notes

Reaction equation

HRID 167853 reaction equation
[Br:3][CH2:4][CH:5]1[CH2:6][CH2:7][CH2:8]1.[I:2].[Mg:1].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[c:9]1([S:15](=[O:16])(=[O:17])[n:18]2[c:19]([C:28](=[O:29])[c:30]3[cH:31][cH:32][c:33]([S:36][CH3:37])[cH:34][cH:35]3)[cH:20][c:21]3[c:22]2[n:23][cH:24][c:25]([F:27])[cH:26]3)[cH:10][cH:11][cH:12][cH:13][cH:14]1>>[CH2:4]([CH:5]1[CH2:6][CH2:7][CH2:8]1)[C:28]([c:19]1[n:18]([S:15]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)(=[O:16])=[O:17])[c:22]2[c:21]([cH:20]1)[cH:26][c:25]([F:27])[cH:24][n:23]2)([OH:29])[c:30]1[cH:31][cH:32][c:33]([S:36][CH3:37])[cH:34][cH:35]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 24841Hydrogen iodideHCID 2734658(Bromomethyl)cyclobutaneHCID 5462224MagnesiumHCID 67228557(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanone

Product 1

HCID 672287211-(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclobutyl-1-(4-methylsulfanyl-phenyl)-ethanol

Sources & evidence

ORD record
ord-017fad4043ff4db3b7a607fb67a4e544
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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