4-Methylmorpholine → HCID 4508198, compound

HRID 1678530Notes

Reaction equation

HRID 1678530 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=2)[CH2:16][CH2:15]1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([NH:26][C:23]1[CH:22]=[CH:21][C:20]([N:17]2[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]2)=[CH:25][CH:24]=1)=[O:7]

Participants

8

Reactant 5

HCID 79724-MethylmorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 668363-Bromo-4-methoxybenzoic acidHCID 757711-HydroxybenzotriazoleHCID 7372534-(4-Methylpiperazin-1-yl)aniline

Product 1

HCID 4508198HCID 4508198, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 3-bromo-4-methoxy-benzoic acid (500 mg), 4-(4-methyl-piperazin-1-yl)-phenylamine (413 mg), EDAC (828 mg), HOBT (534 mg) and N-methylmorpholine (712 μl) in DMF (3 ml) was stirred at room temperature for 18 h. The mixture was then diluted with water (30 ml) and the resulting solid collected by filtration and dried (840 mg)

Workup

  1. filtrationthe resulting solid collected by filtration
  2. customdried (840 mg)

Sources & evidence

ORD record
ord-26357145b2f54ede97bf6c4abfb75c84
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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