反应详情

A mixture of 6-chloro-biphenyl-3,4′-dicarboxylic acid 4′-ethyl ester (152 mg), 4-(4-methanesulfonyl-piperazin-1-ylmethyl)-phenylamine (175 mg), EDAC (125 mg), HOBT (88 mg) and N-methylmorpholine (143 μl) in DMF (3 ml) was stirred at room temperature. After 1 h, water (30 ml) was added and the resulting suspension filtered. The residue was then purified by chromatography. Gradient elution with 30-100% ethyl acetate in petrol gave a beige solid (240 mg).

1. filtrationthe resulting suspension filtered
2. customThe residue was then purified by chromatography
3. washGradient elution with 30-100% ethyl acetate in petrol