Hydrochloric Acid → HCID 67375153, compound

HRID 1678609Notes

Reaction equation

HRID 1678609 reaction equation
C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:29]=[C:30]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:31]=1)[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:19][C:18]=1[F:28])=O)(C)(C)C.[ClH:39]>C(OCC)(=O)C>[ClH:39].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:29]=[C:30]([O:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:31]=1)[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:19][C:18]=1[F:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23136537HCID 23136537, compound

Product 1

HCID 67375153HCID 67375153, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 3-{4-[(3-{2-[(tert-butoxycarbonyl)amino]ethoxy}-5-phenoxybenzyl)oxy]-3-fluorophenyl}propanoic acid (0.20 g, 0.38 mmol) was added a solution of hydrochloric acid in ethyl acetate (4 N, 1 mL), and the mixture was stirred 15 hours. The reaction solution was concentrated under reduced pressure, and the resulting white powders were separated by filtration, washed with ethyl acetate and dried to give the title compound. Yield 89%.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting white powders were separated by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-4ff42f00d85a4ed797e2fc5259a12d87
Source dataset
uspto-grants-2011_08
Patent number
US08008525B2

Reaction notes

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