Lithium Hydroxide → HCID 67131223, compound

HRID 1678656Notes

Reaction equation

HRID 1678656 reaction equation
C([O:3][C:4](=[O:38])[C:5]1[CH:10]=[CH:9][C:8]([C:11]([C:20]2[N:21]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=3)[N:22]=[C:23]3[C:28]=2[CH:27]=[C:26]([F:29])[C:25]([F:30])=[CH:24]3)([CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[O:12][CH3:13])=[CH:7][CH:6]=1)C.[OH-].[Li+]>C1COCC1.CO>[Cl:37][C:34]1[CH:35]=[CH:36][C:31]([N:21]2[C:20]([C:11]([CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)([O:12][CH3:13])[C:8]3[CH:9]=[CH:10][C:5]([C:4]([OH:38])=[O:3])=[CH:6][CH:7]=3)=[C:28]3[C:23]([CH:24]=[C:25]([F:30])[C:26]([F:29])=[CH:27]3)=[N:22]2)=[CH:32][CH:33]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67131002HCID 67131002, compound

Product 1

HCID 67131223HCID 67131223, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-4-{[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methoxymethyl}-benzoic acid ethyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as colorless foam. MS: m/e=511.3 [M+H+].

Sources & evidence

ORD record
ord-be4f576a73424e099af1f170a0a3a96d
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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