Lithium Hydroxide → HCID 67131065, compound

HRID 1678657Notes

Reaction equation

HRID 1678657 reaction equation
C([O:3][C:4](=[O:36])[C:5]1[CH:10]=[CH:9][C:8]([C:11]([C:20]2[N:21]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[N:22]=[C:23]3[C:28]=2[CH2:27][CH2:26][CH2:25][CH2:24]3)([CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[O:12][CH3:13])=[CH:7][CH:6]=1)C.[OH-].[Li+]>C1COCC1.CO>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([N:21]2[C:20]([C:11]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)([O:12][CH3:13])[C:8]3[CH:7]=[CH:6][C:5]([C:4]([OH:36])=[O:3])=[CH:10][CH:9]=3)=[C:28]3[C:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)=[N:22]2)=[CH:30][CH:31]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67131207HCID 67131207, compound

Product 1

HCID 67131065HCID 67131065, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-4-{[2-(4-chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-cyclohexyl-methoxymethyl}-benzoic acid ethyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as off-white solid. MS: m/e=479.3 [M+H+].

Sources & evidence

ORD record
ord-1af7e5e3310643948b76ccd936c8f25c
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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