Lithium Hydroxide → HCID 45111802, compound

HRID 1678679Notes

Reaction equation

HRID 1678679 reaction equation
C[O:2][C:3]([C:5]1([O:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH:17]([C:24]3[N:25]([C:33]4[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=4)[N:26]=[C:27]4[C:32]=3[CH:31]=[CH:30][CH:29]=[CH:28]4)[CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:11][CH:10]=2)[CH2:7][CH2:6]1)=[O:4].[OH-].[Li+]>C1COCC1.CO>[Cl:39][C:36]1[CH:37]=[CH:38][C:33]([N:25]2[C:24]([CH:17]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH2:16][O:15][C:12]3[CH:11]=[CH:10][C:9]([O:8][C:5]4([C:3]([OH:4])=[O:2])[CH2:6][CH2:7]4)=[CH:14][CH:13]=3)=[C:32]3[C:27]([CH2:28][CH2:29][CH2:30][CH2:31]3)=[N:26]2)=[CH:34][CH:35]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 45111663HCID 45111663, compound

Product 1

HCID 45111802HCID 45111802, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-1-(4-{2-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-2-cyclohexyl-ethoxy}-phenoxy)-cyclopropanecarboxylic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as yellow oil. MS: m/e=533.2 [M−H−].

Sources & evidence

ORD record
ord-cb9ce45a7c6947ae896d343261af6218
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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