Lithium Hydroxide → HCID 45111803, compound

HRID 1678681Notes

Reaction equation

HRID 1678681 reaction equation
C[O:2][C:3]([C:5]1([O:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH:16]([C:23]3[N:24]([C:34]4[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=4)[N:25]=[C:26]4[C:31]=3[CH:30]=[C:29]([F:32])[C:28]([F:33])=[CH:27]4)[CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[CH:11][CH:10]=2)[CH2:7][CH2:6]1)=[O:4].[OH-].[Li+]>C1COCC1.CO>[Cl:40][C:37]1[CH:38]=[CH:39][C:34]([N:24]2[C:23]([CH:16]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[O:15][C:12]3[CH:13]=[CH:14][C:9]([O:8][C:5]4([C:3]([OH:4])=[O:2])[CH2:7][CH2:6]4)=[CH:10][CH:11]=3)=[C:31]3[C:26]([CH:27]=[C:28]([F:33])[C:29]([F:32])=[CH:30]3)=[N:25]2)=[CH:35][CH:36]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67131159HCID 67131159, compound

Product 1

HCID 45111803HCID 45111803, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-1-(4-{[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methoxy}-phenoxy)-cyclopropanecarboxylic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as colorless liquid. MS: m/e=553.3 [M+H+].

Sources & evidence

ORD record
ord-41d9c63d5f744392bbbe408140643107
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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