2-Pyrrolidone → 2-METHOXY-10-[1-(1-Pyrrolin-2-YL)-2-PYRROLIN-2-YL]PHENOTHIAZINE

HRID 1678855Notes

Reaction equation

HRID 1678855 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]=2[CH:4]=1.[NH:17]1[CH2:21][CH2:20][CH2:19][C:18]1=O.P(Cl)(Cl)(Cl)=O>ClCCCl>[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([C:18]3[N:17]([C:18]4[CH2:19][CH2:20][CH2:21][N:17]=4)[CH2:21][CH2:20][CH:19]=3)[C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 120252-PyrrolidoneHCID 24813Phosphorus oxychlorideHCID 74490Methyl phenothiazin-2-yl ether

Product 1

HCID 127993922-METHOXY-10-[1-(1-Pyrrolin-2-YL)-2-PYRROLIN-2-YL]PHENOTHIAZINE

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Reaction of 2-methoxyphenothiazine, 2-pyrrolidinone and phosphorus oxychloride in 1,2-dichloroethane according to the procedure of Example 1 affords 2-METHOXY-10-[1-(1-Pyrrolin-2-YL)-2-PYRROLIN-2-YL]PHENOTHIAZINE free base, m.p. 151°-153° C. (corr.), from isopropyl alcohol.

Sources & evidence

ORD record
ord-78ff48b7d7c1464b9bf1c35dc3807ec2
Source dataset
uspto-grants-1978_03
Patent number
US04077959

Reaction notes

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