Dimethylformamide → HCID 178462992, compound

HRID 1679042Notes

Reaction equation

HRID 1679042 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[N:9][C:10]3[N:14]([CH2:15][CH3:16])[N:13]=[CH:12][C:11]=3[C:6]=2[N:5]2[N:17]=[CH:18][N:19]=[C:4]2[N:3]=1.CN(C)C=O.[S-2:25].[Na+].[Na+]>C(O)(=O)C>[CH2:15]([N:14]1[C:10]2[N:9]=[CH:8][C:7]3[C:2]([SH:25])=[N:3][C:4]4[N:5]([N:17]=[CH:18][N:19]=4)[C:6]=3[C:11]=2[CH:12]=[N:13]1)[CH3:16]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 14804Sodium SulfideHCID 227584865-Chloro-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidine

Product 1

HCID 178462992HCID 178462992, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.6 g. of 5-chloro-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine (0.02 mol.) are dissolved in 100 ml. of dimethylformamide. 2 g. of powdered sodium sulfide are added and the mixture is stirred for 1 hour. After this time, the solution is carefully acidifed with acetic acid. 8-Ethyl-8H-pyrazolo[3',4':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine-5-thiol precipitates and is filtered off.

Workup

  1. custom8-Ethyl-8H-pyrazolo[3',4':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine-5-thiol precipitates
  2. filtrationis filtered off

Sources & evidence

ORD record
ord-94e93faee8464e64878690229afabfac
Source dataset
uspto-grants-1978_03
Patent number
US04078064

Reaction notes

Loading…