Potassium Iodide → HCID 70548763, compound

HRID 1680179Notes

Reaction equation

HRID 1680179 reaction equation
[C:1]12([NH:12][C:13](=[O:17])[CH2:14][CH2:15][Cl:16])[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.C(=O)([O-])O.[Na+].[I-].[K+]>C(OCC)C>[ClH:16].[C:1]12([NH:12][C:13](=[O:17])[CH2:14][CH2:15][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 8082PiperidineHCID 516892Sodium BicarbonateHCID 53823875HCID 53823875, compound

Product 1

HCID 70548763HCID 70548763, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 1.00 g (3.91 millimoles) of N-(1-tricyclo[4.3.1.12,5 ]undecyl)-3-chloropropionamide and 0.33 g (3.91 millimoles) of piperidine in 20 ml of diethyl ether was added 6 ml of an aqueous solution containing 0.27 g (3.91 millimoles) of sodium hydrogencarbonate and 0.065 g (0.39 millimole) of potassium iodide, and the mixture was refluxed under stirring for 6 hours. The post treatment was carried out in the same manner as described in Example 1 to obtain 1.00 g (the yield being 75%) of the intended compound having a melting point of 207° to 212° C.

Workup

  1. temperaturethe mixture was refluxed
  2. customto obtain 1.00 g (the yield

Sources & evidence

ORD record
ord-a3947005046f4c818944a8bfd4e54d01
Source dataset
uspto-grants-1981_06
Patent number
US04272536

Reaction notes

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