Potassium Iodide → HCID 70550409, compound

HRID 1680181Notes

Reaction equation

HRID 1680181 reaction equation
[C:1]12([NH:12][C:13](=[O:16])[CH2:14][Cl:15])[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C(=O)([O-])O.[Na+].[I-].[K+]>C(O)C>[ClH:15].[C:1]12([NH:12][C:13](=[O:16])[CH2:14][N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 8082PiperidineHCID 516892Sodium BicarbonateHCID 53852481HCID 53852481, compound

Product 1

HCID 70550409HCID 70550409, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.50 g (6.2 millimoles) of N-(1-tricyclo[4.3.1.12,5 ]undecyl)-2-chloroacetamide and 0.53 g (6.2 millimoles) of piperidine in 50 ml of ethanol was added 10 ml of an aqueous solution containing 0.52 g (6.2 millimoles) of sodium hydrogencarbonate and 0.10 g (0.62 millimole) of potassium iodide, and the mixture was refluxed, under agitation, for 10 hours. The post treatment was carried out in the same manner as described in section (B) of Example 1 to obtain 1.63 g (the yield being 81%) of the intended compound having a melting point of 174° to 176° C. (recrystallized from methanolacetone).

Workup

  1. temperaturethe mixture was refluxed, under agitation, for 10 hours
  2. customto obtain 1.63 g (the yield
  3. customa melting point of 174° to 176° C. (recrystallized from methanolacetone)

Sources & evidence

ORD record
ord-a3ee169101c644e98d8a8bb58cdded83
Source dataset
uspto-grants-1981_06
Patent number
US04272536

Reaction notes

Loading…