Hydrochloric Acid → 1-[3-(8-Hydroxy-6-azaspiro[2.5]octan-6-yl)propyl]-3-methyl-4-[3-(trifluoromethoxy)phenyl]piperazin-2-one
Reaction equation
[BH3:47].[CH2:25]1[CH2:26][C:27]12[CH:28]([OH:33])[CH2:29][NH:30][CH2:31][CH2:32]2.[CH3:1][CH:2]1[C:3](=[O:23])[N:4]([CH2:19][CH2:20][CH:21]=[O:22])[CH2:5][CH2:6][N:7]1[c:8]1[cH:9][c:10]([O:14][C:15]([F:16])([F:17])[F:18])[cH:11][cH:12][cH:13]1.[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:48][CH2:49][OH:50].[Cl:51][CH2:52][Cl:53].[ClH:24].[cH:54]1[cH:55][cH:56][n:57][cH:58][cH:59]1.[n:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[CH3:1][CH:2]1[C:3](=[O:23])[N:4]([CH2:19][CH2:20][CH2:21][N:30]2[CH2:29][CH:28]([OH:33])[C:27]3([CH2:25][CH2:26]3)[CH2:32][CH2:31]2)[CH2:5][CH2:6][N:7]1[c:8]1[cH:9][c:10]([O:14][C:15]([F:16])([F:17])[F:18])[cH:11][cH:12][cH:13]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-fce04749b4b54766adb17b60967ae543
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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