Dimethylthiocarbamoyl chloride → HCID 23454946, compound

HRID 1680894Notes

Reaction equation

[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([N:14]([CH3:16])[CH3:15])=[S:13])=[CH:7][CH:6]=1)=[O:2].[C:17](NNC1C=CC(N)=CC=1)(=O)C.CN(C)C(Cl)=S.C(N(CC)C(C)C)(C)C>>[C:1]([NH:3][NH:4][C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([N:14]([CH3:16])[CH3:15])=[S:13])=[CH:9][CH:10]=1)(=[O:2])[CH3:17]

Participants

Reactant 4

HCID 27871Dimethylthiocarbamoyl chloride

HCID 81068Acetic acid, 2-(4-aminophenyl)hydrazide

HCID 81531Diisopropylethylamine

HCID 23454953HCID 23454953, compound

Product 1

HCID 23454946HCID 23454946, compound

Procedure

The procedure for the preparation of NA-1 in Example 1 was followed with 1-acetyl-2-(4-aminophenyl)hydrazine (0.82 g, 0.005 mole), dimethylthiocarbamoyl chloride (0.62 g, 0.005 mole) and N,N-diisopropylethylamine (0.65 g, 0.005 mole). Yield 0.30 g (24 percent), m.p. 187°-189° C.

Sources & evidence

ORD record: ord-6cdf09f407404029a54d47ab8b1c0579
Source dataset: uspto-grants-1981_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04276364

Reaction notes

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