Hydrochloric Acid → HCID 19806562, compound

HRID 1681384Notes

Reaction equation

HRID 1681384 reaction equation
C([O:3][CH:4](OCC)[C:5]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[CH3:16])[CH:8]=[CH:7][C:6]=1[N+:17]([O-:19])=[O:18])C.Cl.O>C(O)(C)C>[CH3:16][C:12]1[N:11]([C:9]2[CH:8]=[CH:7][C:6]([N+:17]([O-:19])=[O:18])=[C:5]([CH:10]=2)[CH:4]=[O:3])[CH:15]=[CH:14][N:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 19806560HCID 19806560, compound

Product 1

HCID 19806562HCID 19806562, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 5-(2-methylimidazol-1-yl)-2-nitrobenzaldehyde diethyacetal (735 mg), conc-HCl (2.0 ml), water (4.0 ml) and isopropyl alcohol (4.0 ml) was heated under stirring for 1 hour and cooled. The mixture was extracted with dichloromethane and the extract was dried with Na2SO4 and filtered. The filtrate was distilled to give 494 mg (88%) of the title compound.

Workup

  1. temperaturecooled
  2. extractionThe mixture was extracted with dichloromethane
  3. dry with materialthe extract was dried with Na2SO4
  4. filtrationfiltered
  5. distillationThe filtrate was distilled

Sources & evidence

ORD record
ord-7fa34cf2bd5442cda3f08528396d4f70
Source dataset
uspto-grants-1992_12
Patent number
US05171851

Reaction notes

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