反应详情

To a mixture of 1.2 g trifluoroacetic acid and 1.2 g triethylamine in 200 ml dry dichloromethane 8.3 g (90 mmol, 90% proof) 2-methoxyacrylonitrile (J. Chem. Soc. 520, 1942) are added. Thereafter 28.5 g N-benzyl-N-methoxymethyl-N-(trimethylsilylmethyl)amine (Chem. Letters 1117, 1984) are added, and the mixture is stirred overnight at room temperature. The mixture is treated with a saturated solution of sodium hydrogencarbonate, dried with magnesium sulfate, and finally the organic solvents are removed in vacuo and the residue is distilled.

1. additionare added
2. dry with materialdried with magnesium sulfate
3. customfinally the organic solvents are removed in vacuo
4. distillationthe residue is distilled