HRID1681675

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6495

2,2-Dimethoxypropane

C5H12O2

结构：CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

HCID452306

Pantethine

C22H42N4O8S2

PRODUCTS

生成物

结构：CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO.[CH2-]C(C)=O

HCID178450587

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID6422

未命名化合物

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 1.0 g of D-pantethine, 5 ml of 2,2-dimethoxypropane, 5 drops of trifluoroacetic acid and 5 ml of acetone was stirred for 2 days and then evaporated. The resulting white foam was purified by flash chromatography [dichloromethane:methanol (10:1)], giving 1.0 g of the desired compound as a white hygroscopic foam.

WORKUP

后处理

customevaporated
customThe resulting white foam was purified by flash chromatography [dichloromethane:methanol (10:1)]

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-026ceb9ae02f4d6caab782b05ebeefc8
来源数据集: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05173510
来源说明: uspto-grants-1992_12

反应 SMILES

[CH3:1][C:2]([C@@H:6]([OH:36])[C:7]([NH:9][CH2:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][S:17][S:18][CH2:19][CH2:20][NH:21][C:22]([CH2:24][CH2:25][NH:26][C:27]([C@H:29]([OH:35])[C:30]([CH2:33][OH:34])([CH3:32])[CH3:31])=[O:28])=[O:23])=[O:13])=[O:8])([CH2:4][OH:5])[CH3:3].C[O:38][C:39](OC)([CH3:41])[CH3:40]>FC(F)(F)C(O)=O.CC(C)=O>[CH3:3][C:2]([C@@H:6]([OH:36])[C:7]([NH:9][CH2:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][S:17][S:18][CH2:19][CH2:20][NH:21][C:22]([CH2:24][CH2:25][NH:26][C:27]([C@H:29]([OH:35])[C:30]([CH2:33][OH:34])([CH3:31])[CH3:32])=[O:28])=[O:23])=[O:13])=[O:8])([CH2:4][OH:5])[CH3:1].[CH2-:40][C:39]([CH3:41])=[O:38]