Hydrochloric Acid → HCID 67561418, compound

HRID 1683126Notes

Reaction equation

HRID 1683126 reaction equation
C(O)=O.CO.C([N:13]1[CH2:18][CH2:17][C:16]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)([C:19]([NH2:21]=O)=[O:20])[CH2:15][CH2:14]1)C1C=CC=CC=1.Cl.C(OCC)C>CO.C(OCC)(=O)C.[Pt]>[ClH:29].[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:16]2([C:19]([NH2:21])=[O:20])[CH2:15][CH2:14][NH:13][CH2:18][CH2:17]2)=[CH:24][CH:25]=1

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 18963719Formic acid methanolHCID 88283885HCID 88283885, compound

Product 1

HCID 67561418HCID 67561418, compound

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 887MethanolSolvent3×HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1/9 by volume of formic acid/methanol (50 mL) was carefully added to platinum black (2.2 g). A solution of 1-benzyl-4-(4-chloro-phenyl)-piperidine-4-carboxylic acid amide N-oxide (2.6 g) in methanol (10 mL) was added. After 18 hours, the reaction mixture was filtered through a bed of celite and the filtrate was evaporated in vacuo to give a residue. The residue was dissolved in ethyl acetate (10 mL) and a 1M solution of hydrochloric acid in methanol (4 mL) added. The reaction mixture was evaporated in vacuo to give a residue which was dissolved in methanol and treated with diethyl ether to give a solid. The solid was collected by filtration and dried to give the title compound.

Workup

  1. filtrationthe reaction mixture was filtered through a bed of celite
  2. customthe filtrate was evaporated in vacuo
  3. customto give a residue
  4. customThe reaction mixture was evaporated in vacuo
  5. customto give a residue which
  6. customto give a solid
  7. filtrationThe solid was collected by filtration
  8. customdried

Sources & evidence

ORD record
ord-9fe53cb4fd6548eb9342a55eadca4c60
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

Loading…