2,6-Dimethylaniline → N-(2,6-dimethylphenyl)-2-methoxyacetamide
Reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[CH3:10][O:11][CH2:12][C:13](O)=[O:14]>>[CH3:10][O:11][CH2:12][C:13]([NH:4][C:3]1[C:5]([CH3:9])=[CH:6][CH:7]=[CH:8][C:2]=1[CH3:1])=[O:14]Participants
3
Procedure
According to the process described in the HU-PS 202,481, after acylating 2,6-dimethylaniline with methoxyacetic acid, the N-methoxyacetyl-2,6-dimethylaniline obtained is heated together with a twofold excess of methyl DL-α-bromopropionate to 120° C., and after adding sodium methoxide in small portions to the reaction mixture obtained, the alkylation is carried out at 140° C.
Sources & evidence
- ORD record
- ord-174a8a78610640b18084f1c96cc4a474
- Source dataset
- uspto-grants-1997_06
- Patent number
- US05639905
Reaction notes
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