Potassium Carbonate → HCID 19039064, compound

HRID 1684452Notes

Reaction equation

HRID 1684452 reaction equation
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][CH:9]1[CH2:14][CH2:13][Si:12]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.[F:26][C:27]([F:37])([F:36])[O:28][C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=1>CN(C)C=O>[F:26][C:27]([F:36])([F:37])[O:28][C:29]1[CH:30]=[CH:31][C:32]([O:35][CH2:8][CH:9]2[CH2:14][CH2:13][Si:12]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[CH:33][CH:34]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 70015p-(Trifluoromethoxy)phenolHCID 19039124HCID 19039124, compound

Product 1

HCID 19039064HCID 19039064, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

8.3 g (60 mmols) of potassium carbonate was added to a mixture of 6.8 g (20 mmols) of 4-bromomethyl-1-n-pentyl-1-phenyl-1-silacyclohexane, 3.6 g (20 mmols) of 4-trifluoromethoxyphenol and 50 ml of dimethylformamide (DMF), followed by heating under flux for 10 hours. The reaction mixture was after-treated by a usual manner and purified through chromatography to obtain 6.4 g (yield: 73%) of 4-(4-trifluoromethoxyphenyloxymethyl)-1-n-pentyl-1-phenyl-1-silacyclohexane. The results of IR and NMR analyses are shown below.

Workup

  1. temperatureby heating under flux for 10 hours
  2. additionThe reaction mixture was after-treated by a usual manner
  3. custompurified through chromatography

Sources & evidence

ORD record
ord-b4c3d38e48e94135acccc91fe1367566
Source dataset
uspto-grants-1997_06
Patent number
US05641430

Reaction notes

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