HCID 57700027, compound → HCID 136000909, compound

HRID 1686008Notes

Reaction equation

HRID 1686008 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:20][C:21]3[CH:26]=[CH:25][C:24]([NH:27][C:28](=[O:35])[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:23][CH:22]=3)=[C:14]([Br:19])[CH:15]=[N:16]2)=[CH:11][C:10]=1[O:36][CH3:37])C1C=CC=CC=1>C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>[C:28]([NH:27][C:24]1[CH:25]=[CH:26][C:21]([O:20][C:13]2[C:12]3[C:17](=[CH:18][C:9]([OH:8])=[C:10]([O:36][CH3:37])[CH:11]=3)[N:16]=[CH:15][C:14]=2[Br:19])=[CH:22][CH:23]=1)(=[O:35])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

4

Reactant 1

HCID 57700027HCID 57700027, compound

Product 1

HCID 136000909HCID 136000909, compound

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidSolventHCID 7520ThioanisoleSolvent

Procedure

A mixture of N-[4-(7-benzyloxy-3-bromo-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide (35 mg, 0.063 mmol) in TFA (1 ml) and thioanisole (80 μl) was refluxed for 4 hours, cooled and concentrated under high vacuum.

Workup

  1. temperaturewas refluxed for 4 hours
  2. temperaturecooled
  3. concentrationconcentrated under high vacuum

Sources & evidence

ORD record
ord-b1be0ab8632f4f40bd77c82596c713c8
Source dataset
uspto-grants-2012_04
Patent number
US08148531B2

Reaction notes

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