HCID 67264705, compound → HCID 136387228, compound

HRID 1686009Notes

Reaction equation

HRID 1686009 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:22][C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:37])[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:25][CH:24]=3)=[C:14]([CH:19]3[CH2:21][CH2:20]3)[CH:15]=[N:16]2)=[CH:11][C:10]=1[O:38][CH3:39])C1C=CC=CC=1>C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>[C:30]([NH:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:13]2[C:12]3[C:17](=[CH:18][C:9]([OH:8])=[C:10]([O:38][CH3:39])[CH:11]=3)[N:16]=[CH:15][C:14]=2[CH:19]2[CH2:21][CH2:20]2)=[CH:24][CH:25]=1)(=[O:37])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

4

Reactant 1

HCID 67264705HCID 67264705, compound

Product 1

HCID 136387228HCID 136387228, compound

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidSolventHCID 7520ThioanisoleSolvent

Procedure

A mixture of N-[4-(7-benzyloxy-3-cyclopropyl-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide (50 mg, 0.097 mmol) in TFA (750 μl) and thioanisole (90 μl) was refluxed for 1 hour, cooled and concentrated under high vacuum to use crude in the next stage.

Workup

  1. temperaturewas refluxed for 1 hour
  2. temperaturecooled
  3. concentrationconcentrated under high vacuum

Sources & evidence

ORD record
ord-5e80a447825e4c639ff3218cf2119b5e
Source dataset
uspto-grants-2012_04
Patent number
US08148531B2

Reaction notes

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