Hydrochloric Acid → HCID 66686258, compound

HRID 1686027Notes

Reaction equation

HRID 1686027 reaction equation
[CH3:1][C:2]1[NH:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:4]=2[C:3]=1[CH3:20].[ClH:21]>C(OCC)(=O)C>[ClH:21].[CH3:1][C:2]1[NH:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:4]=2[C:3]=1[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11708802HCID 11708802, compound

Product 1

HCID 66686258HCID 66686258, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,3-dimethyl-4-(4-fluorobenzylamino)-1H-pyrrolo[3,2-c]pyridine (1.44 g, 5.34 mmol) prepared in Example 32 was dissolved in ethyl acetate (10 ml). The reaction mixture was saturated with hydrochloric acid gas and then filtered to give the titled compound as a white solid. (Yield: 82.5%)

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-6423cfd6a44b42feb7cd6fdf6fd1a81e
Source dataset
uspto-grants-2012_04
Patent number
US08148529B2

Reaction notes

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