1,2-Dichloroethane → HCID 25017920, compound

HRID 1686050Notes

Reaction equation

HRID 1686050 reaction equation
[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][C:26]4([C:29]([OH:31])=O)[CH2:28][CH2:27]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:32])[NH:6]2.C[CH2:34][N:35](C(C)C)[CH:36](C)C.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.Cl.CNC>C(Cl)Cl>[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][C:26]4([C:29]([N:35]([CH3:36])[CH3:34])=[O:31])[CH2:28][CH2:27]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:32])[NH:6]2

Participants

7

Reactant 5

HCID 111,2-DichloroethaneHCID 10473Dimethylamine, hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 25017921HCID 25017921, compound

Product 1

HCID 25017920HCID 25017920, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of Example 10 (100 mg) was mixed with DIPEA (1.5 eq), EDC (1.25 eq), HOBt (1 eq) and dimethylamine hydrochloride (3 eq) in DCM (20 ml). The reaction was stirred at RT overnight and washed with NaHCO3 solution, dried. The solution was evaporated and purified with silica gel column to give the titled product (80 mg). Mass: (M+1), 464

Workup

  1. washwashed with NaHCO3 solution
  2. customdried
  3. customThe solution was evaporated
  4. custompurified with silica gel column

Sources & evidence

ORD record
ord-b09d1d488dea4f619c1f1bb8c0817a9f
Source dataset
uspto-grants-2012_04
Patent number
US08148532B2

Reaction notes

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