反应详情

Lithium hydroxide (5.00 g) was added to a stirred mixture of ethyl 2-butylthiazole-4-carboxylate (example 78, step f) (6.50 g) in THF (80 mL) and water (20 mL). After 16 h, concentrated hydrochloric acid (10 mL) was added and the solution concentrated to ˜40 mL. The reaction mixture was partitioned between ethyl acetate and brine. The aqueous layer was extracted three times with ethyl acetate. The combined organic layers were dried over magnesium sulphate, filtered and evaporated in vacuo to give the subtitled compound as an off white solid. Yield 4.6 g.

1. concentrationthe solution concentrated to ˜40 mL
2. customThe reaction mixture was partitioned between ethyl acetate and brine
3. extractionThe aqueous layer was extracted three times with ethyl acetate
4. dry with materialThe combined organic layers were dried over magnesium sulphate
5. filtrationfiltered
6. customevaporated in vacuo