反应详情

To a solution of 1,2:5,6-Di-O-isopropylidene-α-D-allofuranose (30A) (obtained from Pfanstiehl Laboratories Inc.) (40 g) in dimethylformamide at 0° C. was added sodium hydride in smaller portions. The reaction mixture was stirred for 1 h, benzyl bromide was added drop wise over a period of 1 h. The reaction mixture was stirred at room temperature for 16 h. Methanol was added to quench the reaction and dimethylformamide was removed under pressure. The syrup was extracted with ethyl acetate and washed with brine. Evaporation of the ethyl acetate layer yielded a semisolid (93%). Homogeneous by TLC.

1. stirringThe reaction mixture was stirred at room temperature for 16 h
2. customto quench
3. customthe reaction and dimethylformamide
4. customwas removed under pressure
5. extractionThe syrup was extracted with ethyl acetate
6. washwashed with brine
7. customEvaporation of the ethyl acetate layer