HRID1690227

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1068

Dimethyl sulfide

C2H6S

HCID24758

Sodium hydride

HNa

结构：COC(=O)[C@H](NC(=O)OC(C)(C)C)c1ccccc1

HCID10967413

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H](c1ccccc1)N(C)C(=O)OC(C)(C)C

HCID57788115

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

To (R)-methyl 2-(tert-butoxycarbonylamino)-2-phenylacetate (E4) in DMF at −40° C. was added NaH and the solution was warmed to 0° C. for 20 minutes. DMS was added and solution was stirred at room temperature for 3 hours. The mixture was poured into NH4Cl(sat)/HCl (1N) 3:1 and extracted with EtOAc. The organics were dried (Na2SO4), filtered and evaporated to give crude E5. Column chromatography Hexanes/EtOAc gave pure (R)-methyl 2-(tert-butoxycarbonyl (methyl)amino)-2-phenylacetate (E5).

WORKUP

后处理

extractionextracted with EtOAc
dry with materialThe organics were dried (Na2SO4)
filtrationfiltered
customevaporated