Triethylamine → HCID 66905435, compound

HRID 1690603Notes

Reaction equation

HRID 1690603 reaction equation
[CH:1]1([NH:7][C:8]2[N:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:10]=[C:11]3[C:16]=2[CH2:15][CH2:14][CH2:13][CH2:12]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:23][O:24][C:25](=[O:36])[C:26]1[CH:31]=[CH:30][C:29]([N:32]=[C:33]=[O:34])=[C:28]([Cl:35])[CH:27]=1.C(N(CC)CC)C>ClCCCl>[CH3:23][O:24][C:25](=[O:36])[C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33]([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8]2[N:9]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:10]=[C:11]3[C:16]=2[CH2:15][CH2:14][CH2:13][CH2:12]3)=[O:34])=[C:28]([Cl:35])[CH:27]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 45111767HCID 45111767, compoundHCID 866402623-Chloro-4-isocyanato-benzoic acid methyl ester

Product 1

HCID 66905435HCID 66905435, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

In analogy to the procedure described in example 1.2, cyclohexyl-(2-phenyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-amine (example 45) was reacted with 3-chloro-4-isocyanato-benzoic acid methyl ester (example 9.1) in 1,2-dichloroethane in the presence of triethylamine for 120 h under reflux conditions to give the title compound as yellow solid. MS: m/e=507.2 [M+H+].

Sources & evidence

ORD record
ord-e5e066c357ed47608b236815e601be83
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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