Hydrochloric Acid → HCID 59255450, compound

HRID 1691337Notes

Reaction equation

HRID 1691337 reaction equation
[O:1]1CCO[CH:2]1[C:6]1[CH:19]=[CH:18][C:9]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:8][C:7]=1[F:20].O1CCCC1.Cl.C(=O)([O-])O.[Na+]>CO>[F:20][C:7]1[CH:8]=[C:9]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH:18]=[CH:19][C:6]=1[CH:2]=[O:1]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 592555252-(4-[1,3]Dioxolan-2-yl-3-fluorobenzyloxy)-pyridine

Product 1

HCID 59255450HCID 59255450, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(4-[1,3]dioxolan-2-yl-3-fluoro-benzyloxy)-pyridine (2.17 g, 7.88 mmol) described in Manufacturing Example 204-1-4 in methanol (10 mL) and tetrahydrofuran (10 mL) was added 5 N hydrochloric acid (8.43 mL, 8.43 mmol). This solution was stirred for 15 minutes at room temperature. This mixture was cooled to 0° C. and neutralized with a saturated sodium hydrogencarbonate aqueous solution, after which it was extracted with ethyl acetate. The organic layer was separated, washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (1.81 g). The title compound was used in the following reaction without any further purification.

Workup

  1. temperatureThis mixture was cooled to 0° C.
  2. extractionafter which it was extracted with ethyl acetate
  3. customThe organic layer was separated
  4. washwashed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated under a reduced pressure

Sources & evidence

ORD record
ord-b3b31aa8dc494e6fbd8b6fbf08033832
Source dataset
uspto-grants-2012_04
Patent number
US08153662B2

Reaction notes

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