Sodium hydride → HCID 24966676, compound

HRID 1693123Notes

Reaction equation

HRID 1693123 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:8]=[CH:7][C:6]=1[NH2:17])(=[O:4])=[O:3].[F:18][C:19]1[CH:32]=[CH:31][C:22]2[S:23][C:24]([S:27](Cl)(=[O:29])=[O:28])=[C:25]([CH3:26])[C:21]=2[CH:20]=1.[H-].[Na+]>O1CCCC1>[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C:11]2[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=2)[CH:8]=[CH:7][C:6]=1[NH:17][S:27]([C:24]1[S:23][C:22]2[CH:31]=[CH:32][C:19]([F:18])=[CH:20][C:21]=2[C:25]=1[CH3:26])(=[O:29])=[O:28])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chlorideHCID 59759965HCID 59759965, compound

Product 1

HCID 24966676HCID 24966676, compoundYield 5.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared in analogy to Example 20f starting from 2-methanesulfonyl-4-pyridin-4-yl-phenylamine (cf. Example 20c, 0.27 g) in tetrahydrofurane (10 ml) and 5-fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride (0.265 g) with sodium hydride (0.10 g) at rt for 18 h to obtain the title compound (0.025 g) as a yellow foam. MS (ISN): 475.0 (M−H)−

Workup

  1. customThis compound was prepared in analogy to Example 20f

Sources & evidence

ORD record
ord-a4cba459ce9e449d8ad77d2d8aad3c16
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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