反应详情

A mixture of 2,8-dibromoquinoline (4.64 g, 16 mmol, prepared by the method of L. Mao et al., Tetrahedron Lett. 46 (2005) 8419), 3,5-di-tert-butyl-2-methoxyphenylboronic acid (4.3 g, 16 mmol), K2CO3 (5.6 g, 40 mmol), Pd(OAc)2 (0.08 g, 0.3 mmol), P(o-Tol)3 (0.2 g, 0.6 mmol), dimethoxyethane (40 mL) and water (10 mL) is refluxed for 8 h with stirring in an argon atmosphere. The mixture is then poured into water and extracted with CHCl3 (3×50 mL). The combined organic phase is washed with water and brine, and then concentrated. The residue is purified by column chromatography (silica gel 40, hexane/CH2Cl24:1). Yield: 5.2 g (77%).

1. customprepared by the method of L
2. extractionextracted with CHCl3 (3×50 mL)
3. washThe combined organic phase is washed with water and brine
4. concentrationconcentrated
5. customThe residue is purified by column chromatography (silica gel 40, hexane/CH2Cl24:1)