Hydrochloric Acid → HCID 54587659, compound

HRID 1694710Notes

Reaction equation

HRID 1694710 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[O:20][CH2:21][C:22]([O:24]CC)=[O:23].[OH-].[Na+].Cl>C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([S:8]([CH2:11][CH3:12])(=[O:9])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[O:20][CH2:21][C:22]([OH:24])=[O:23]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86609217HCID 86609217, compound

Product 1

HCID 54587659HCID 54587659, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the product from step (v) (2.23 g), 1M aqueous sodium hydroxide (10 ml) and THF (20 ml) was stirred at RT for 3 h. The mixture was acidified with 2M hydrochloric acid, extracted with diethylether and the organics washed with water, dried, and evaporated under reduced pressure. The residue was recrystallised from ethylacetate/isohexane, yield 0.45 g.

Workup

  1. extractionextracted with diethylether
  2. washthe organics washed with water
  3. customdried
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallised from ethylacetate/isohexane, yield 0.45 g

Sources & evidence

ORD record
ord-a0ee6080cce94ec0bcfe1d69c96ed12f
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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