反应详情

温度

80 °C

Sodium hydride (0.128 g, 60% disp. in oil) was added to a stirred solution of 2-methyl-1,2,5-thiadiazolidine 1,1-dioxide (0.433 g) in THF (10 ml). DMF (10 ml) was added and the mixture heated at 80° C. for 5 min then a solution of the product from step (i) (0.8 g) in DMF (5 ml) was added. The mixture was heated at 60° C. for 10 min, poured into water (100 ml), acidified with citric acid and extracted with ethylacetate. The organics were evaporated under reduced pressure and the residue purified by chromatography on silica eluting with diethylether, yield 0.58 g.

1. temperatureThe mixture was heated at 60° C. for 10 min
2. extractionextracted with ethylacetate
3. customThe organics were evaporated under reduced pressure
4. customthe residue purified by chromatography on silica eluting with diethylether, yield 0.58 g