反应详情

Sodium hydride (0.33 g) was added to a solution of the product from step (i) (1.2 g) in DMF (25 ml) and stirred for 20 min. Methyl iodide (0.5 ml) was added dropwise and then stirred for a further 1 h. The reaction mixture was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was treated with ether to give to give the subtitle compound as a white solid. Yield 0.45 g.

1. stirringstirred for a further 1 h
2. customThe reaction mixture was quenched with water
3. extractionextracted with EtOAc
4. dry with materialdried (MgSO4)
5. customevaporated
6. additionThe residue was treated with ether
7. customto give