Trifluoroacetic acid → HCID 178436122, compound

HRID 1694804Notes

Reaction equation

HRID 1694804 reaction equation
[CH:1]1([C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH3:11])[C:5]=2[CH:12]([C:14]2[N:15]=[CH:16][N:17](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:18]=2)O)[CH2:3][CH2:2]1.C([SiH](CC)CC)C.FC(F)(F)C(O)=O>ClCCl>[CH:1]1([C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH3:11])[C:5]=2[CH2:12][C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951933HCID 58951933, compound

Product 1

HCID 178436122HCID 178436122, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in analogy to Example 57(e) from rac-(2-cyclopropyl-6-ethyl-phenyl)-(1-trityl-1H-imidazol-4-yl)-methanol, triethylsilane and trifluoroacetic acid in dichloromethane. Off-white crystalline solid. MS (ISP): 227.4 ([M+H]+).

Sources & evidence

ORD record
ord-37566e7a61a24584a4d1689252c67fd8
Source dataset
uspto-grants-2012_04
Patent number
US08158668B2

Reaction notes

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