Lithium Hydroxide → Benzenesulfonic acid, 4-amino-, monolithium salt

HRID 1695075Notes

Reaction equation

HRID 1695075 reaction equation
[S:1]([OH:11])(=[O:10])([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1)=[O:2].[Li+:12].[OH-]>O>[Li+:12].[S:1]([O-:11])(=[O:10])([C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[CH:7][CH:8]=1)=[O:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 8479Sulfanilic acid

Product 1

HCID 44149263Benzenesulfonic acid, 4-amino-, monolithium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Next, a sulfanilate lithium salt precursor is prepared according to step 2 in FIG. 8. Sulfanilic acid (1.35 g, 7.8 mmol) and LiOH (0.187 g, 7.8 mmol) were added in water (10 mL) with constant stirring. This step results in an available lone pair of electrons on the amino group to react with the acid chloride at the next and final step. After stirring 20 min, the clear solution was then dried in vacuum overnight to obtain a dried sulfanilate lithium salt precursor. The solid was used as the starting material in the final step.

Workup

  1. customNext, a sulfanilate lithium salt precursor is prepared
  2. customThis step results in an available lone pair of electrons on the amino group
  3. customthe clear solution was then dried in vacuum overnight

Sources & evidence

ORD record
ord-e8aaf55cd7a341caa09c7e5caf38581d
Source dataset
uspto-grants-2012_04
Patent number
US08163204B2

Reaction notes

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