反应详情

温度

20 °C

Butyl lithium (15 ml, 1.9M in hexanes) was added over 40 min to a solution of the product from step b) (6.82 g) and triisopropylborate (8.0 ml) in THF (30 ml) at −78° C. and stirred for a further 1 h. 2M HCl (20 ml) was added, the mixture was warmed to 20° C. and extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol—ether as eluent) to give the sub-title compound (1.82 g).

1. extractionextracted with ether (three times)
2. dry with materialThe organic extracts were dried (MgSO4)
3. customevaporated
4. custompurified by chromatography (silica, petrol—ether as eluent)