Chloroform → N-{3-[3-cyclopropyl-5-(2-fluoro-4-trimethylsilanylethynylphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide

HRID 169513Notes

Reaction equation

HRID 169513 reaction equation
[CH3:42][Si:43]([CH3:44])([CH3:45])[C:46]#[CH:47].[CH3:50][CH2:51][N:52]([CH2:53][CH3:54])[CH2:55][CH3:56].[CH:1]1([n:4]2[c:5](=[O:37])[n:6](-[c:27]3[cH:28][c:29]([NH:33][C:34]([CH3:35])=[O:36])[cH:30][cH:31][cH:32]3)[c:7]3[c:8]([c:9]2=[O:10])[c:11]([NH:18][c:19]2[c:20]([F:26])[cH:21][c:22]([I:25])[cH:23][cH:24]2)[n:12]([CH3:17])[c:13](=[O:16])[c:14]3[CH3:15])[CH2:2][CH2:3]1.[CH:38]([Cl:39])([Cl:40])[Cl:41].[Cu:48][I:49]>>[CH:1]1([n:4]2[c:5](=[O:37])[n:6](-[c:27]3[cH:28][c:29]([NH:33][C:34]([CH3:35])=[O:36])[cH:30][cH:31][cH:32]3)[c:7]3[c:8]([c:9]2=[O:10])[c:11]([NH:18][c:19]2[c:20]([F:26])[cH:21][c:22]([C:47]#[C:46][Si:43]([CH3:42])([CH3:44])[CH3:45])[cH:23][cH:24]2)[n:12]([CH3:17])[c:13](=[O:16])[c:14]3[CH3:15])[CH2:2][CH2:3]1

Participants

6

Reactant 5

HCID 6212ChloroformHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 11707110Trametinib

Product 1

HCID 59717184N-{3-[3-cyclopropyl-5-(2-fluoro-4-trimethylsilanylethynylphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide

Sources & evidence

ORD record
ord-27da8979b25749b6a81b8dd99492e678
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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