Stannous chloride dihydrate → HCID 67272092, compound

HRID 1696505Notes

Reaction equation

HRID 1696505 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:10])[CH:8]=2)[CH:3]=[N:2]1.[N:11]([O-])=O.[Na+].O.O.[Cl:17][Sn]Cl>Cl>[ClH:17].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:10][NH2:11])[CH:8]=2)[CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 61436Stannous chloride dihydrateHCID 814231H-Indazol-6-amineHCID 23668193Sodium Nitrite

Product 1

HCID 67272092HCID 67272092, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent2×

Procedure

To a solution of 1H-indazol-6-ylamine (20 g, 153 mmol) in conc. HCl (50 mL) was added an aqueous solution (50 mL) of NaNO2 (19 g, 158 mmol) at 0° C. and the resulting mixture was stirred for 1 h. A solution of SnCl2.2H2O (90 g, 306 mmol) in conc. HCl (70 mL) pre-cooled to 0° C. was then added, and the mixture stirred for 2 h at RT. The precipitate was filtered and washed with Et2O to yield (1H-indazol-6-yl)-hydrazine hydrochloride as a yellow solid, which was used without further purification.

Workup

  1. additionwas then added
  2. stirringthe mixture stirred for 2 h at RT
  3. filtrationThe precipitate was filtered
  4. washwashed with Et2O

Sources & evidence

ORD record
ord-f2f03989ea7646d8908a7cffe694b251
Source dataset
uspto-grants-2012_04
Patent number
US08163756B2

Reaction notes

Loading…