HCID 67275357, compound → HCID 67275055, compound

HRID 1696891Notes

Reaction equation

HRID 1696891 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]=[C:22]3[C:17]([C:18](=[O:40])[C:19]([C:35]([O:37]CC)=[O:36])=[CH:20][N:21]3[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=3[O:33][CH3:34])=[C:16]([CH3:41])[C:15]=2[F:42])[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Li+].[OH-].C1COCC1.ClCCl>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]=[C:22]3[C:17]([C:18](=[O:40])[C:19]([C:35]([OH:37])=[O:36])=[CH:20][N:21]3[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=3[O:33][CH3:34])=[C:16]([CH3:41])[C:15]=2[F:42])[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 1

HCID 67275357HCID 67275357, compound

Product 1

HCID 67275055HCID 67275055, compound

Reagents, catalysts & solvents 3

HCID 3939Lithium HydroxideSolventHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 1E (332 mg) in 1M LiOH (3 mL) and THF (7 mL) was stirred at ambient temperature for 18 hours, diluted with dichloromethane, washed with 1M HCl, and dried (Na2SO4), filtered, and concentrated.

Workup

  1. washwashed with 1M HCl
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-ce61f28ed72b42a4bfdb5ed8002fb96e
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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