Lithium Hydroxide → HCID 67275458, compound

HRID 1696907Notes

Reaction equation

HRID 1696907 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:12][N:11]([C:13]2[N:22]=[C:21]3[C:16]([C:17](=[O:32])[C:18]([C:27]([O:29]CC)=[O:28])=[CH:19][N:20]3[CH2:23][CH2:24][C:25]#[N:26])=[CH:15][C:14]=2[F:33])[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li+].[OH-]>C1COCC1.CO>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:12][N:11]([C:13]2[N:22]=[C:21]3[C:16]([C:17](=[O:32])[C:18]([C:27]([OH:29])=[O:28])=[CH:19][N:20]3[CH2:23][CH2:24][C:25]#[N:26])=[CH:15][C:14]=2[F:33])[CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67274679HCID 67274679, compound

Product 1

HCID 67275458HCID 67275458, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of EXAMPLE 20A (0.41 g) in THF (60 mL) and methanol (30 mL) at reflux was treated with 1M LiOH (100 mL), stirred for 3 hours then cooled, concentrated to half volume, acidified with 10% citric acid (90 mL), and filtered.

Workup

  1. temperaturethen cooled
  2. concentrationconcentrated to half volume
  3. filtrationfiltered

Sources & evidence

ORD record
ord-a3d45dbc04e14f84baa4d5c7abd663b0
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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