Lithium Hydroxide → HCID 67275167, compound

HRID 1696921Notes

Reaction equation

HRID 1696921 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:24]=[C:23]3[C:18]([C:19](=[O:34])[C:20]([C:29]([O:31]CC)=[O:30])=[CH:21][N:22]3[CH2:25][CH2:26][C:27]#[N:28])=[CH:17][C:16]=2[F:35])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li+].[OH-]>C1COCC1.CO>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:24]=[C:23]3[C:18]([C:19](=[O:34])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3[CH2:25][CH2:26][C:27]#[N:28])=[CH:17][C:16]=2[F:35])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67275302HCID 67275302, compound

Product 1

HCID 67275167HCID 67275167, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of EXAMPLE 66A (0.71 g) in THF (100 mL) and methanol (50 mL) at reflux was treated with 1M LiOH (100 mL), stirred for 3 hours, concentrated to half volume, acidified with 10% citric acid, and filtered.

Workup

  1. concentrationconcentrated to half volume
  2. filtrationfiltered

Sources & evidence

ORD record
ord-7bd0c3e232d84a38b3d1399af456a01a
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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