Potassium Carbonate → HCID 67275514, compound

HRID 1696926Notes

Reaction equation

HRID 1696926 reaction equation
[C:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12](Cl)[N:13]=2)[C:8](=[O:16])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:6]1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>ClCCl>[C:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[N:13]=2)[C:8](=[O:16])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium Carbonate2×HCID 31268Pyrrolidine2×HCID 86615483HCID 86615483, compound

Product 1

HCID 67275514HCID 67275514, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 73C (210 mg), potassium carbonate (150 mg), and pyrrolidine (113 μl) in dichloromethane was stirred for 3 days, treated with potassium carbonate (150 mg) and pyrrolidine (113 μL), stirred for 3 more days, and concentrated; and the concentrate was purified by flash column chromatography on silica gel with a methanol/dichloromethane gradient.

Workup

  1. concentrationconcentrated
  2. customand the concentrate was purified by flash column chromatography on silica gel with a methanol/dichloromethane gradient

Sources & evidence

ORD record
ord-bf16d9845b0849bb83fadaa65153f053
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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