Sodium hydride → HCID 131729659, compound

HRID 1697844Notes

Reaction equation

HRID 1697844 reaction equation
[H-].[Na+:2].[SH:3][CH2:4][CH:5]([CH:9]1[CH2:11][CH2:10]1)[C:6]([OH:8])=[O:7]>CN(C)C=O>[Na+:2].[Na+:2].[SH:3][CH2:4][CH:5]([CH:9]1[CH2:11][CH2:10]1)[C:6]([O-:8])=[O:7].[SH:3][CH2:4][CH:5]([CH:9]1[CH2:11][CH2:10]1)[C:6]([O-:8])=[O:7]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 57012192HCID 57012192, compound

Product 1

HCID 131729659HCID 131729659, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
2.5 °C

Procedure

In a light-protected flask and under N2 atmosphere, 4.4 g of 60% sodium hydride and 88 ml of dimethylformamide were mixed. To this mixture, a solution containing 8.1 g of mercaptomethylcyclopropylacetic acid and 20 ml of dimethylformamide was added while maintaining the temperature at 0-5° C. The reaction mixture was kept at this temperature for 1 hour.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-3c51c4e5afc948f790faf9075c64b29a
Source dataset
uspto-grants-2012_04
Patent number
US08163924B2

Reaction notes

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