反应详情

温度

90 °C

A mixture of 3-bromo-6-((4-methoxybenzyl)oxy)benzaldehyde (4 g), Zn(CN)2 (1 g) and Pd(PPh3)4 (4.32 g) in 40 mL DMF was stirred at 90° C. for 3 hours, cooled to ambient temperature and diluted with 100 mL 50% NH4OH. The aqueous layer was extracted with ethyl acetate (3×). The organic layer was dried, concentrated and purified on silica gel column (ethyl acetate/hexane, 1:4) to afford 2.8 g of 3-cyano-6-((4-methoxybenzyl)oxy)benzaldehyde as a yellow solid.

1. temperaturecooled to ambient temperature
2. extractionThe aqueous layer was extracted with ethyl acetate (3×)
3. customThe organic layer was dried
4. concentrationconcentrated
5. custompurified on silica gel column (ethyl acetate/hexane, 1:4)