反应详情

2-[Dodecylamino]ethanol (2.0 g, 8.73 mmol), 1-iodoethane (1.63 g, 10.48 mmol) and N,N-diisopropylethylamine (2.51 g, 17.5 mmol) in isopropanol (25 ml )were heated under reflux for 4 h. The solvent was then evaporated in vacuo and the residue was diluted with ethyl acetate washed with aqueous sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent followed by chromatography on silica gel (ethyl acetate/methanol 90:10 to 80:20) afforded the title compound (1.65 g, 73%) as a white solid.

1. temperatureunder reflux for 4 h
2. customThe solvent was then evaporated in vacuo
3. additionthe residue was diluted with ethyl acetate
4. washwashed with aqueous sodium bicarbonate, brine
5. dry with materialdried (magnesium sulfate)
6. customEvaporation of the solvent