Sodium hydride → HCID 54464238, compound

HRID 1702886Notes

Reaction equation

HRID 1702886 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:14][NH:13][C:12]2=[O:22])=[CH:7][CH:6]=1.[CH3:23][O:24][C:25](=[O:34])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]Br>CN(C=O)C>[CH3:23][O:24][C:25](=[O:34])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][N:13]1[CH:14]=[C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:11]([C:8]2[CH:7]=[CH:6][C:5]([O:4][CH3:3])=[CH:10][CH:9]=2)[C:12]1=[O:22]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 12418987HCID 12418987, compound

Product 1

HCID 54464238HCID 54464238, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 2.4 g of NaH (80% suspension in mineral oil), 21.3 g of 1-(4-methoxyphenyl)-5-phenyl-4-imidazolin-2-one, 160 cc. of DMF 19 g of 8-bromocaprylic acid methyl ester and 2.4 g of NaJ. Eluant in chromatographic purification: hexane/ethyl acetate.

Workup

  1. customThe product is produced
  2. customEluant in chromatographic purification

Sources & evidence

ORD record
ord-bafcbc20f8a4461eb750a414a7887afd
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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